Saturday, July 21, 2012

Police fire rubber bullets after huge Madrid protest

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Source: http://news.yahoo.com/spain-workers-plan-mass-demos-against-cuts-181530139.html

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Sequencing of Single Sperm Could Reveal New Infertility Causes

News | Health

Sperm, decoded: a technological achievement parses the genomes of individual sperm cells, showing a new way to study reproductive medicine and hereditary cancer


Sex cells, decoded: New technology has allowed scientists to sequence single sex cells from one individual to track rates of mutation--and possibly search for causes of infertility. Image: Layla Lang/layla@laylalang.com

Less than a decade after the first full human genome was mapped, technology has arrived to decode the full genome of a single sex cell. The ability promises to offer new insight into the causes of infertility, the development of mutations and the diversity of the human genome.

Sperm and egg cells differ from other bodily cells in that they have a single?rather than double?set of chromosomes. Researchers have successfully amplified and sequenced 91 sperm cells from a single individual, a 40-year-old man whose genome has already been sequenced and analyzed?an important factor for checking the accuracy of the sperm sequencing. They found that the sampled sperm had sustained about 23 recombinations, which help to mix up genes from the chromosomes to increase genetic diversity in offspring, and between 25 and 36 new mutations, rates that match previous estimations for those in the general population. The scientists reported the findings online July 19 in Cell.

The new capability is "going to allow us to answer a lot of questions about genome stability in the germ line," says Don Conrad, a human geneticist at Washington University School of Medicine in Saint Louis, who was not involved with the new research. The researchers found that although the man who donated the sperm already had healthy offspring, two of the sperm cells studied were each missing a full chromosome. Such mutations, however, make it less likely that a sperm cell will successfully fertilize an egg.

Until now, we have made rough estimates about genetic mutations and recombination on the population scale. "We haven't had the tools to quantify those things on a personal level," Conrad says. "This is a technological breakthrough." Stephen Quake of the Stanford School of Medicine's Department of Bioengineering and his team have been working on this project for the past decade. "We started with bacteria and worked our way up to humans," he says. They harnessed developments in the field of micro-fluidics to sequence the single cells on chips. These micro-fluidic chips allowed them to amplify the genome (with a process called multiple displacement amplification) using far less material, which reduced the odds for contamination?and thus erroneous findings?by 1,000 times, they reported.

The approach also revealed new places where mutations seem to congregate on the genome?so-called hot spots. Although the study was not designed to pinpoint particular biological signals, it demonstrates "how little we actually knew about hot spots across the genome," Quake says. And future research can use these findings?and technology?to start to probe bigger biological questions, such as "to help understand and potentially diagnose reproductive disorders, to help understand what happens when it's the man's fault," he says.

Reproductive technologists, however, will not be sequencing sperm to screen them for implantation anytime soon. The current method of sequencing destroys the sperm cell subject. Quake, however, suggests that both screening and capturing a sperm cell intact is possible under the right conditions?namely, just before a sperm cell splits through meiosis. "If you can capture them before they separate, you can sequence one and you'll know what the other is."

Source: http://rss.sciam.com/click.phdo?i=b2fb1728f6c48a08d0bafaa623a6d751

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Scientists Learn How to Turn Innovations into Jobs

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Source: http://news.yahoo.com/scientists-learn-turn-innovations-jobs-113051336.html

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Sunday, July 15, 2012

Video: Japan floods kill at least 25

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Source: http://video.msnbc.msn.com/nightly-news/48190501/

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BlackListedNews: 27 Things That Every American Should Know About The National Debt http://t.co/bXUdTCQn

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Source: http://twitter.com/BlackListedNews/statuses/224378269162680322

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PressTV: Italian troops injured in#Afghanistan http://t.co/RHTYr8DG

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Source: http://twitter.com/PressTV/statuses/224477806237724673

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British troops have to provide Olympics security after contractor fails

LONDON ? Now the British military is being asked to ?mind the gap? ? in security.

London?s Olympic organizers reeled Friday from the fallout of revelations that 3,500 British troops? some of them just back from tours in Afghanistan ? would need to step in and help guard venues for the upcoming Olympics. That?s because the security contractor, G4S, failed in its promise to deliver more than 10,000 security guards ? and didn?t let anyone know until the last moment.

With only two weeks to go before the games, the embarrassing development made organizers squirm. London games chair Sebastian Coe, who had sailed on a cascade of positive news so far, found himself trying to explain why the games? sole security provider and a sponsor had produced such a mess.

?It?s only when the rubber hits the road that you understand some of things that you need (to) address,? Coe told reporters Friday. ?When the rubber hit the road and we looked at some of the retention, some of the recruitment ? we made a very quick and very robust and prudent and judicious decision to act as we did.?

The problems started to emerge only a few weeks ago. G4S failed to provide enough security guards when the stadium and the aquatics center were ?locked down?? a process that involves putting in place the tightest security ahead of the games. The government started asking questions and as late as Wednesday, G4S was suggesting they could still deliver. By Thursday, Home Secretary Theresa May was facing lawmakers outraged about the debacle and the decision to send in more troops, bringing the total number of armed forces involved in the project to 17,000.

Security has been a critical concern for the Olympics ever since 11 Israeli athletes and coaches died in a terror attack at the 1972 Munich Games. British authorities have planned for a threat level for the London games of ?severe,? meaning an attack is ?highly likely.?

London itself has also been touched by terrorism, when four suicide bombers killed 52 commuters on July 7, 2005 ? the day after London was awarded the games. A huge international media presence makes the Olympics a prime target for any terror group intent on wreaking havoc on live events broadcast worldwide.

Some security analysts suggested the games might be better off by having servicemen and women around rather than guards whose training might be substandard.

While the guards issue centers on securing the venues, critics wondered whether the tone of overall securityfor the games will shift. National Olympic security coordinator, Chris Allison, wants it to be remembered as a blue games ? or dominated by police ? rather than a khaki games ? or something like the militarized look of Beijing.

?We still have many many more G4S people on this site at this very moment than the military,? Coe said while on a tour of the new water polo arena.

He suggested that athletes would be unconcerned about the changes.

?I?ve never seen athletes of any level, either from university sport or Olympic finalists, breaking off their warm-up routines to go and have their photographs taken with the military.?

It was not the first time the security mix needed to be changed for games costing the British taxpayer 9.3 billion pounds ($14.6 billion). The total cost of securing the venues climbed to over 553 million pounds ($862 million) ? not including money for the police or the new cost added by the soldiers.

Critics demanded that G4S face fines ? and even Prime Minister David Cameron said companies who don?t deliver on their contracts should be ?be pursued for that money.?

G4S, which has over 657,000 employees operating in more than 125 countries, chalked up the problems to issues vetting and recruiting staff. But comments from apparent applicants posted online painted a picture of broad-based mismanagement, disorganization and even squandered opportunities.

Potential guards took to the company?s Olympics Facebook page to plead for information about where their accreditation passes and uniforms were. Others wondered when they would get their shifts, why they had been approved and vetted but not received any more details on when to turn up and how they would be employed.

Applicant Jimmy Schofield, 32, said he had been bogged down in the hiring process since March.

?I feel like pulling my hair out,? he said. ?All l want to do is work. I turned down job offers because l was told l would be working at the Olympics.?

Some potential guards were angry and said they had been vetted and qualified but never received marching orders ? only to learn that the armed forces would be called in. Others had been vetted but still needed training.

As early as last year, Britain?s National Audit Office was warning that ?the need for additional manpower has also produced a significant recruitment challenge.?

?They over-extended themselves,? said Peter Fussey, author of ?Securing and Sustaining the Olympic City,? and an expert on security and the Olympics. ?This was very foreseeable.?

Coe told reporters the shortfall would not harm the reputation of the London Games.

?Good competitors never worry about what the crowd is doing,? said the former track star who owns twoOlympic gold medals. ?I?ve never ever heard, listened, seen people sitting in the stand when I was a competitor. That?s something that goes on out there. We just deliver regardless of who is there.?

Source: http://bangordailynews.com/2012/07/13/sports/olympics/british-troops-have-to-provide-olympics-security-after-contractor-fails/

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